Brennan BP, Jensen JE, Hudson JI, Coit CE, Beaulieu A, Pope HG, Renshaw PF, Cohen BM. J Clin Psychopharmacol. 2013.

Alpha-lipoic acid plus acetyl-l-carnitine (Pure Encapsulations) administered at daily doses of 1000-3000 mg and 600-1800 mg, respectively, does not reduce bipolar depression according to a 12 week randomized, placebo-controlled study of 40 adults. More study is needed to understand the role of mitochondrial function in depression.