L Fung, R Libove, J Phillips, F Haddad, A Hardan. J Autism Dev Disord. 2014. 12 week, open-label pilot study in adults with autism spectrum disorder yielded statistically significant improvement in aberrant behavior (irritability) with pregnenolone supplementation.
Modulation of strawberry/cranberry phenolic compounds glucuronidation by co-supplementation with onion: characterization of phenolic metabolites in rat plasma using an optimized μSPE−UHPLC-MS/MS method
Dudonné S, Dubé P, Pilon G, et al. J Ag Food Chem. 2014. Phenolic metabolites of fruit polyphenols were identified and quantified in vivo using an animal model of obesity. Results indicated a potential synergistic effect on bioavailability when polyphenols were administered with onion extract, a significant source of quercetin.
Short-term supplementation with a specific combination of dietary polyphenols increases energy expenditure & alters substrate metabolism in overweight subjects
Most J, Goossens G, Jocken J, et al. Int J Obes. 2014. Epigallocatechin-gallate plus resveratrol supplementation for 3 days significantly increased fasting and postprandial energy expenditure in healthy overweight subjects.
Effect of the probiotic Saccharomyces boulardii on cholesterol & lipoprotein particles in hypercholesterolemic adults: A single-arm, open-label pilot study
Ryan J, Hanes D, Schafer M, et al. J Altern Comp Med. 2015. In this pilot study, 8 weeks of daily supplementation with S. boulardii showed potential benefit for cardiovascular health.
Effect of selenium supplementation on CD4R T-cell recovery, viral suppression and morbidity of HIV-infected patients in Rwanda: a randomized controlled trial
Kamwesiga J, Mutabazi V, Kayumba J, et al. AIDS. 2015. This randomized clinical trial demonstrated that 24-month selenium supplementation significantly reduces the rate of CD-4 cell count decline among antiretroviral-naive patients.
A randomized trial of nutrient supplements to minimize psychiatric illness after a natural disaster
Kaplan B, Rucklidge J, Romijn A, et al. Psych Res. 2015. Replication of New Zealand trial investigating the consumption of micronutrients following a disaster and the potential benefits for mental health and mood support.
The safety & efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: a randomized, double-blind, placebo-controlled trial
Bolten W, Glade M, Raum S, et al. Arthritis. 2015. Systemic enzymes in adults with moderate-to-severe knee osteoarthritis showed improvement in pain scores (Lequesne Functional Index) and total WOMAC scores similar to NSAID (diclofenac).
Proteolytic enzyme combination reduces inflammation and oxidative stress & improves insulin sensitivity in a model of metabolic syndrome
Talaieva T, Bratus V. Adv Enzyme Res. 2015. In a rabbit model of diet-induced MetS, animals supplemented with systemic enzymes showed improvement in insulin sensitivity, inflammatory markers, triglyceride metabolism, and lipid metabolism.
Impact of systemic enzyme supplementation on low-grade inflammation in humans
Paradis M-E, Couture P, Gigleux I, et al. Pharma Nutr. 2015. Systemic enzymes promoted healthy inflammatory balance in men and women with subclinical inflammation. Overall, subjects showed reduced IL-6 levels, with sex-specific effects that require further study.
Effect of DHA-rich fish oil on PPARγ target genes related to lipid metabolism in type 2 diabetes: A randomized, double-blind, placebo-controlled clinical trial
Mansoori A, Sotoudeh G, Djalali M, et al. J Clin Lipidol. 2015. 8 weeks of supplementation with DHA-rich fish oil (containing 1450 mg DHA and 400 mg EPA) supported triglyceride metabolism.
Effect of Vitamin D3 supplementation in black & in white children: a randomized, placebo-controlled trial
Rajakumar K, Moore CG, Yabes J, et al. J Clin Endocrinol Metab. 2015. Concluded current recommended daily dietary allowance of Vitamin D may not be adequate for reducing the incidence of vitamin D insufficiency in healthy school-aged children.
Double-blind randomized placebo-controlled clinical trial of omega 3 fatty acids for the treatment of diabetic patients with nonalcoholic steatohepatitis
Dasarathy S, Dasarathy J, Khiyami A, et al. J Clin Gastroenterol. 2015. PUFA showed no benefit over placebo in NASH patients with diabetes in terms of liver enzymes, body weight, or body composition, and did not show a positive impact on insulin response.