The SNP Peek series brings you concise, up-to-date information on genetic variations known as Single Nucleotide Polymorphisms (SNPs), which affect a significant percentage of patients. The SNPs featured in this series are clinically relevant, nutritionally actionable and validated by published research. Featuring one SNP at a time, the series will educate you/readers/viewers about prevalence, important research findings, targeted nutritional supplements and monitoring. To apply this information in practice quickly and easily, visit
Who is Affected?

Data from case-control studies suggest that at least 9% of Canadians, 17% of Americans, and 17% of the Chinese population carry this SNP.2

Clinical Relevance:

Mental health. The MTHFR A1298C polymorphism may decrease the production of certain neurotransmitters such as serotonin and catecholamines.


The Research:

Studies have indicated that A1298C is associated with the incidence and severity of mood concerns.3-4
Folate is required for the synthesis of neurotransmitters that support mood, such as serotonin and dopamine. Metafolin® (L-5-MTHF) bypasses MTHFR to ensure folate adequacy.5 5-MTHF is at least as effective as folic acid in elevating markers of folate status.

Pure Encapsulations® Products
Folate 1000 provides 1000 mcg per capsule of Metafolin®, a clinically researched 5-MTHF.
PureGenomics® Multivitamin
provides comprehensive support with a complete foundation of vitamins and minerals, including essential methylation cofactors such as vitamins B6 and B12. This once-daily formula also provides 1.7 mg of riboflavin and 1.7 mg of the activated MTHFR cofactor, riboflavin 5’-phosphate.
Suggested Monitoring:
Homocysteine. While seldom elevated in patients with the A1298C SNP alone, high homocysteine is common in patients who are heterozygous (+/-) for both C677T and A1298C.1 If elevated, retest after 3-6 months.
About PureGenomics®
PureGenomics® combines a platform of educational tools and core products with our dynamic, practitioner-exclusive website application designed to identify common genetic variations known as Single Nucleotide Polymorphisms (SNPs) that are clinically relevant and nutritionally actionable. This unique platform makes it easy to TEST, TRANSLATE and TARGET SNPs with the right nutritional support, empowering practitioners with precision and confidence in the pursuit of optimal health for every patient.